'In vivo electrophysiology' is a sophisticated technique used in neuroscience to study the electrical activities of neurons in freely behaving animals. This method involves the use of twisted microwires, known as tetrodes, which are adept at detecting action potentials from nearby neurons. By employing this technique, we can record both local field potentials and the spiking activity of neurons in real-time as the animals engage in their natural behaviors.
This approach is particularly valuable in understanding the dynamics of neural circuits during various behaviors and how these circuits are altered in pathological conditions. For instance, my lab's research on mouse models of Alzheimer's disease, in vivo electrophysiology is crucial. It allows for the monitoring of neuronal responses during different behaviors and observing how these responses change as the disease progresses. This provides invaluable insights into the neural mechanisms underlying Alzheimer's disease and contributes to the development of potential therapies.
Description
In Vivo Electrophysiology
Technique
Optogenetic silencing of medial septal GABAergic neurons disrupts grid cell spatial and temporal coding in the medial entorhinal cortex
Grid cell disruption in a mouse model of early Alzheimer’s disease reflects reduced integration of self-motion cues
Hippocampal Neural Circuits Respond to Optogenetic Pacing of Theta Frequencies by Generating Accelerated Oscillation Frequencies
The medial entorhinal cortex is necessary for temporal organization of hippocampal neuronal activity
New and Distinct Hippocampal Place Codes Are Generated in a New Environment during Septal Inactivation
In Vivo Electrophysiology is used in these papers
'In vivo electrophysiology' is a sophisticated technique used in neuroscience to study the electrical activities of neurons in freely behaving animals. This method involves the use of twisted microwires, known as tetrodes, which are adept at detecting action potentials from nearby neurons. By employing this technique, we can record both local field potentials and the spiking activity of neurons in real-time as the animals engage in their natural behaviors.
This approach is particularly valuable in understanding the dynamics of neural circuits during various behaviors and how these circuits are altered in pathological conditions. For instance, my lab's research on mouse models of Alzheimer's disease, in vivo electrophysiology is crucial. It allows for the monitoring of neuronal responses during different behaviors and observing how these responses change as the disease progresses. This provides invaluable insights into the neural mechanisms underlying Alzheimer's disease and contributes to the development of potential therapies.
Description
